[PDF][PDF] The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease
P Bai, C Cantó - Cell metabolism, 2012 - cell.com
P Bai, C Cantó
Cell metabolism, 2012•cell.comWhile originally described as DNA damage repair agents, recent data suggest a role for poly
(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing
mitochondrial function and oxidative metabolism. Here we review how PARP activity has a
major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic
complications.
(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing
mitochondrial function and oxidative metabolism. Here we review how PARP activity has a
major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic
complications.
While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.
cell.com