[HTML][HTML] Function-blocking integrin αvβ6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes
PH Weinreb, KJ Simon, P Rayhorn, WJ Yang… - Journal of Biological …, 2004 - ASBMB
We have generated a panel of potent, selective monoclonal antibodies that bind human and
mouse α v β 6 integrin with high affinity (up to 15 pm). A subset of these antibodies blocked
the binding of α v β 6 to the transforming growth factor-β1 latency-associated peptide with IC
50 values as low as 18 pm, and prevented the subsequent α v β 6-mediated activation of
transforming growth factor-β1. The antibodies also inhibited α v β 6 binding to fibronectin.
The blocking antibodies form two biochemical classes. One class, exemplified by the ligand …
mouse α v β 6 integrin with high affinity (up to 15 pm). A subset of these antibodies blocked
the binding of α v β 6 to the transforming growth factor-β1 latency-associated peptide with IC
50 values as low as 18 pm, and prevented the subsequent α v β 6-mediated activation of
transforming growth factor-β1. The antibodies also inhibited α v β 6 binding to fibronectin.
The blocking antibodies form two biochemical classes. One class, exemplified by the ligand …