[HTML][HTML] Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent …
GS Bogatkevich, E Tourkina, RM Silver… - Journal of Biological …, 2001 - ASBMB
Myofibroblasts are ultrastructurally and metabolically distinctive fibroblasts that express
smooth muscle (SM)-α actin and are associated with various fibrotic lesions. The present
study was undertaken to investigate the myofibroblast phenotype that appears after
activation of normal lung fibroblasts by thrombin. We demonstrate that thrombin induces
smooth muscle-α actin expression and rapid collagen gel contraction by normal lung
fibroblasts via the proteolytically activated receptor-1 and independent of transforming …
smooth muscle (SM)-α actin and are associated with various fibrotic lesions. The present
study was undertaken to investigate the myofibroblast phenotype that appears after
activation of normal lung fibroblasts by thrombin. We demonstrate that thrombin induces
smooth muscle-α actin expression and rapid collagen gel contraction by normal lung
fibroblasts via the proteolytically activated receptor-1 and independent of transforming …