[HTML][HTML] Coagulation factor Xa cleaves protease‐activated receptor‐1 and mediates signaling dependent on binding to the endothelial protein C receptor
RA Schuepbach, M Riewald - Journal of Thrombosis and Haemostasis, 2010 - Elsevier
Background and objective: Coagulation is intrinsically tied to inflammation, and both
proinflammatory and anti‐inflammatory responses are modulated by coagulation protease
signaling through protease‐activated receptor‐1 (PAR1). Activated factor X (FXa) can elicit
cellular signaling through PAR1, but little is known about the role of cofactors in this
pathway. Endothelial protein C receptor (EPCR) supports PAR1 signaling by the protein C
pathway, and in the present study we tested whether EPCR mediates surface recruitment …
proinflammatory and anti‐inflammatory responses are modulated by coagulation protease
signaling through protease‐activated receptor‐1 (PAR1). Activated factor X (FXa) can elicit
cellular signaling through PAR1, but little is known about the role of cofactors in this
pathway. Endothelial protein C receptor (EPCR) supports PAR1 signaling by the protein C
pathway, and in the present study we tested whether EPCR mediates surface recruitment …