[HTML][HTML] NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells: role in phagocytic …
A Arroyo, M Modrianský, FB Serinkan, RI Bello… - Journal of Biological …, 2002 - ASBMB
Resolution of inflammation requires clearance of activated neutrophils by phagocytes in a
manner that protects adjacent tissues from injury. Mechanisms governing apoptosis and
clearance of activated neutrophils from inflamed areas are still poorly understood. We used
dimethylsulfoxide-differentiated HL-60 cells showing inducible oxidase activity to study
NADPH oxidase-induced apoptosis pathways typical of neutrophils. Activation of the
NADPH oxidase by phorbol myristate acetate caused oxidative stress as shown by …
manner that protects adjacent tissues from injury. Mechanisms governing apoptosis and
clearance of activated neutrophils from inflamed areas are still poorly understood. We used
dimethylsulfoxide-differentiated HL-60 cells showing inducible oxidase activity to study
NADPH oxidase-induced apoptosis pathways typical of neutrophils. Activation of the
NADPH oxidase by phorbol myristate acetate caused oxidative stress as shown by …