Blockade of Orai1 store-operated calcium entry protects against renal fibrosis
X Mai, J Shang, S Liang, B Yu, J Yuan… - Journal of the …, 2016 - journals.lww.com
Evidence supports an important role of Ca 2+ release-activated Ca 2+ channel protein 1
(Orai1)-mediated Ca 2+ entry in the development of renal fibrosis, a common pathologic
feature of CKDs that lead to ESRD, but the molecular mechanisms remain unclear. We
determined the role of Orai1 calcium channel in renal fibrosis induced by high-fat diet and by
unilateral ureteral obstruction. Mouse kidneys with fibrosis had higher levels of Orai1 protein
expression than did kidneys without fibrosis. In vivo knockdown of Orai1 with adenovirus …
(Orai1)-mediated Ca 2+ entry in the development of renal fibrosis, a common pathologic
feature of CKDs that lead to ESRD, but the molecular mechanisms remain unclear. We
determined the role of Orai1 calcium channel in renal fibrosis induced by high-fat diet and by
unilateral ureteral obstruction. Mouse kidneys with fibrosis had higher levels of Orai1 protein
expression than did kidneys without fibrosis. In vivo knockdown of Orai1 with adenovirus …