Visualising the interaction of CD4 T cells and DCs in the evolution of inflammatory arthritis
CT Prendergast, A Patakas, S Al-Khabouri… - Annals of the Rheumatic …, 2018 - Elsevier
Objectives Successful early intervention in rheumatoid arthritis (RA) with the aim of resetting
immunological tolerance requires a clearer understanding of how specificity, cellular kinetics
and spatial behaviour shape the evolution of articular T cell responses. We aimed to define
initial seeding of articular CD4+ T cell responses in early experimental arthritis, evaluating
their dynamic behaviour and interactions with dendritic cells (DCs) in the inflamed articular
environment. Methods Antigen-induced arthritis was used to model articular inflammation …
immunological tolerance requires a clearer understanding of how specificity, cellular kinetics
and spatial behaviour shape the evolution of articular T cell responses. We aimed to define
initial seeding of articular CD4+ T cell responses in early experimental arthritis, evaluating
their dynamic behaviour and interactions with dendritic cells (DCs) in the inflamed articular
environment. Methods Antigen-induced arthritis was used to model articular inflammation …
