[HTML][HTML] Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation
CS Bonilha, RA Benson, HE Scales, JM Brewer… - Immunology …, 2021 - Elsevier
The junctional adhesion molecule-A (JAM-A) is an adhesion molecule present in the surface
of several cell types, such as endothelial cells and leukocytes as well as Dendritic Cells
(DC). Given the potential relevance of JAM-A in diverse pathological conditions such as
inflammatory diseases and cancer, we investigated the role of JAM-A in CD4+ T cell priming.
We demonstrate that JAM-A is present in the immunological synapse formed between T
cells and DC during priming. Furthermore, an antagonistic anti-JAM-A mAb could disrupt the …
of several cell types, such as endothelial cells and leukocytes as well as Dendritic Cells
(DC). Given the potential relevance of JAM-A in diverse pathological conditions such as
inflammatory diseases and cancer, we investigated the role of JAM-A in CD4+ T cell priming.
We demonstrate that JAM-A is present in the immunological synapse formed between T
cells and DC during priming. Furthermore, an antagonistic anti-JAM-A mAb could disrupt the …