[HTML][HTML] Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line: pathways that are shared with and distinct …
D Lejeune, L Dumoutier, S Constantinescu… - Journal of Biological …, 2002 - ASBMB
IL (interleukin)-22 is an IL-10-related cytokine; its main biological activity known thus far is
the induction of acute phase reactants in liver and pancreas. IL-22 signals through a
receptor that is composed of two chains from the class II cytokine receptor family: IL-22R
(also called ZcytoR11/CRF2–9) and IL-10Rβ (CRF2–4), which is also involved in IL-10
signaling. In this report, we analyzed the signal transduction pathways activated in response
to IL-22 in a rat hepatoma cell line, H4IIE. We found that IL-22 induces activation of JAK1 …
the induction of acute phase reactants in liver and pancreas. IL-22 signals through a
receptor that is composed of two chains from the class II cytokine receptor family: IL-22R
(also called ZcytoR11/CRF2–9) and IL-10Rβ (CRF2–4), which is also involved in IL-10
signaling. In this report, we analyzed the signal transduction pathways activated in response
to IL-22 in a rat hepatoma cell line, H4IIE. We found that IL-22 induces activation of JAK1 …