Bone marrow-sparing intensity modulated radiation therapy with concurrent cisplatin for stage IB-IVA cervical cancer: an international multicenter phase II clinical trial …
LK Mell, I Sirák, L Wei, R Tarnawski… - International Journal of …, 2017 - Elsevier
Purpose To test the hypothesis that intensity modulated radiation therapy (IMRT) reduces
acute hematologic and gastrointestinal (GI) toxicity for patients with locoregionally advanced
cervical cancer. Methods and Materials We enrolled patients with stage IB-IVA cervical
carcinoma in a single-arm phase II trial involving 8 centers internationally. All patients
received weekly cisplatin concurrently with once-daily IMRT, followed by intracavitary
brachytherapy, as indicated. The primary endpoint was the occurrence of either acute …
acute hematologic and gastrointestinal (GI) toxicity for patients with locoregionally advanced
cervical cancer. Methods and Materials We enrolled patients with stage IB-IVA cervical
carcinoma in a single-arm phase II trial involving 8 centers internationally. All patients
received weekly cisplatin concurrently with once-daily IMRT, followed by intracavitary
brachytherapy, as indicated. The primary endpoint was the occurrence of either acute …