Amyloid fibril formation and deposition is a common feature of a wide range of fatal diseases
including spongiform encephalopathies, Alzheimer's disease, and familial amyloidotic
polyneuropathies (FAP), among many others. In certain forms of FAP, the amyloid fibrils are
mostly constituted by variants of transthyretin (TTR), a homotetrameric plasma protein.
Recently, we showed that transthyretin in solution may undergo dissociation to a non-native
monomer, even under close to physiological conditions of temperature, pH, ionic strength …