cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y
K Akiyama, K Yokota, S Kagawa, N Shimbara… - Science, 1994 - science.org
K Akiyama, K Yokota, S Kagawa, N Shimbara, T Tamura, H Akioka, HG Nothwang, C Noda…
Science, 1994•science.orgProteasomes are the proteolytic complex responsible for major histocompatibility complex
(MHC) class I-restricted antigen presentation. Interferon γ treatment increases expression of
MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of
two proteasome subunits, named X and Y, which alters the proteolytic specificity of
proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that
their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2 …
(MHC) class I-restricted antigen presentation. Interferon γ treatment increases expression of
MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of
two proteasome subunits, named X and Y, which alters the proteolytic specificity of
proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that
their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2 …
Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen presentation. Interferon γ treatment increases expression of MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of two proteasome subunits, named X and Y, which alters the proteolytic specificity of proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2, respectively. Thus, interferon γ may induce subunit replacements of X and Y by LMP7 and LMP2, respectively, producing proteasomes perhaps more appropriate for the immunological processing of endogenous antigens.
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