found in translation: international initiatives pursuing interleukin-1 blockade for treatment of acute Kawasaki disease
JC Burns, I Koné-Paut, T Kuijpers… - Arthritis & …, 2017 - pmc.ncbi.nlm.nih.gov
JC Burns, I Koné-Paut, T Kuijpers, C Shimizu, A Tremoulet, M Arditi
Arthritis & rheumatology (Hoboken, NJ), 2017•pmc.ncbi.nlm.nih.govThe decision to move forward with three clinical trials of IL-1 blockade for treatment of acute
Kawasaki disease is a case study in translational science. These trials were born on the one
hand from transcriptome studies of host response during the acute disease coupled with
animal model investigations of key immune signaling pathways and, on the other hand, out
of clinical desperation to intervene in patients with severe inflammation in the setting of
acute Kawasaki disease. The convergence of laboratory science and clinical observations …
Kawasaki disease is a case study in translational science. These trials were born on the one
hand from transcriptome studies of host response during the acute disease coupled with
animal model investigations of key immune signaling pathways and, on the other hand, out
of clinical desperation to intervene in patients with severe inflammation in the setting of
acute Kawasaki disease. The convergence of laboratory science and clinical observations …
The decision to move forward with three clinical trials of IL-1 blockade for treatment of acute Kawasaki disease is a case study in translational science. These trials were born on the one hand from transcriptome studies of host response during the acute disease coupled with animal model investigations of key immune signaling pathways and, on the other hand, out of clinical desperation to intervene in patients with severe inflammation in the setting of acute Kawasaki disease. The convergence of laboratory science and clinical observations led to the clinical trials described here and serves as a model for how such observations can be translated into new therapies.
pmc.ncbi.nlm.nih.gov
