[HTML][HTML] Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential

S Basseri, RC Austin - Biochemistry research international, 2012 - hindawi.com
S Basseri, RC Austin
Biochemistry research international, 2012hindawi.com
The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and
secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded
proteins in the ER lumen, a condition referred to as ER stress. In response to ER stress, a
signal transduction pathway known as the unfolded protein response (UPR) is activated.
UPR activation allows the cell to cope with an increased protein-folding demand on the ER.
Recent studies have shown that ER stress/UPR activation plays a critical role in lipid …
The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded proteins in the ER lumen, a condition referred to as ER stress. In response to ER stress, a signal transduction pathway known as the unfolded protein response (UPR) is activated. UPR activation allows the cell to cope with an increased protein-folding demand on the ER. Recent studies have shown that ER stress/UPR activation plays a critical role in lipid metabolism and homeostasis. ER-stress-dependent dysregulation of lipid metabolism may lead to dyslipidemia, insulin resistance, cardiovascular disease, type 2 diabetes, and obesity. In this paper, we examine recent findings illustrating the important role ER stress/UPR signalling pathways play in regulation of lipid metabolism, and how they may lead to dysregulation of lipid homeostasis.
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