Association between titin loss-of-function variants and early-onset atrial fibrillation
Importance Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the
population. Young individuals with AF have a strong genetic association with the disease,
but the mechanisms remain incompletely understood. Objective To perform large-scale
whole-genome sequencing to identify genetic variants related to AF. Design, Setting, and
Participants The National Heart, Lung, and Blood Institute's Trans-Omics for Precision
Medicine Program includes longitudinal and cohort studies that underwent high-depth …
population. Young individuals with AF have a strong genetic association with the disease,
but the mechanisms remain incompletely understood. Objective To perform large-scale
whole-genome sequencing to identify genetic variants related to AF. Design, Setting, and
Participants The National Heart, Lung, and Blood Institute's Trans-Omics for Precision
Medicine Program includes longitudinal and cohort studies that underwent high-depth …