[HTML][HTML] SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status*♦
Mitochondria play a central role in oxidative energy metabolism and age-related diseases
such as cancer. Accumulation of spurious oxidative damage can cause cellular dysfunction.
Antioxidant pathways that rely on NADPH are needed for the reduction of glutathione and
maintenance of proper redox status. The mitochondrial matrix protein isocitrate
dehydrogenase 2 (IDH2) is a major source of NADPH. Previously, we demonstrated that the
NAD+-dependent deacetylase SIRT3 was essential for the prevention of age-related …
such as cancer. Accumulation of spurious oxidative damage can cause cellular dysfunction.
Antioxidant pathways that rely on NADPH are needed for the reduction of glutathione and
maintenance of proper redox status. The mitochondrial matrix protein isocitrate
dehydrogenase 2 (IDH2) is a major source of NADPH. Previously, we demonstrated that the
NAD+-dependent deacetylase SIRT3 was essential for the prevention of age-related …
