[HTML][HTML] Autophagy protects the retina from light-induced degeneration
Y Chen, O Sawada, H Kohno, YZ Le… - Journal of Biological …, 2013 - ASBMB
Autophagy is a conserved feature of lysosome-mediated intracellular degradation.
Dysregulated autophagy is implicated as a contributor in neurodegenerative diseases;
however, the role of autophagy in retinal degeneration remains largely unknown. Here, we
report that the photo-activated visual chromophore, all-trans-retinal, modulated
autophagosome formation in ARPE19 retinal cells. Increased formation of autophagosomes
in these cells was observed when incubated with 2.5 μm all-trans-retinal, a condition that did …
Dysregulated autophagy is implicated as a contributor in neurodegenerative diseases;
however, the role of autophagy in retinal degeneration remains largely unknown. Here, we
report that the photo-activated visual chromophore, all-trans-retinal, modulated
autophagosome formation in ARPE19 retinal cells. Increased formation of autophagosomes
in these cells was observed when incubated with 2.5 μm all-trans-retinal, a condition that did …