Argonaute2 regulates the pancreatic β-cell secretome
SG Tattikota, MD Sury, T Rathjen… - Molecular & Cellular …, 2013 - mcponline.org
Argonaute2 (Ago2) is an established component of the microRNA-induced silencing
complex. Similar to miR-375 loss-of-function studies, inhibition of Ago2 in the pancreatic β-
cell resulted in enhanced insulin release underlining the relationship between these two
genes. Moreover, as the most abundant microRNA in pancreatic endocrine cells, miR-375
was also observed to be enriched in Ago2-associated complexes. Both Ago2 and miR-375
regulate the pancreatic β-cell secretome, and by using quantitative mass spectrometry, we …
complex. Similar to miR-375 loss-of-function studies, inhibition of Ago2 in the pancreatic β-
cell resulted in enhanced insulin release underlining the relationship between these two
genes. Moreover, as the most abundant microRNA in pancreatic endocrine cells, miR-375
was also observed to be enriched in Ago2-associated complexes. Both Ago2 and miR-375
regulate the pancreatic β-cell secretome, and by using quantitative mass spectrometry, we …