Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and Creutzfeldt-Jakob disease
A Dorey, Y Tholance, A Vighetto… - JAMA …, 2015 - jamanetwork.com
Importance Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease
(CJD) are clinically distinguishable, atypical AD phenotypes may pose a diagnostic
challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in
cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia
presentation. Objective To assess the relevance of total CSF prion protein (t-PrP) levels in
the differential biological diagnosis between atypical AD phenotypes and CJD. Design …
(CJD) are clinically distinguishable, atypical AD phenotypes may pose a diagnostic
challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in
cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia
presentation. Objective To assess the relevance of total CSF prion protein (t-PrP) levels in
the differential biological diagnosis between atypical AD phenotypes and CJD. Design …