[HTML][HTML] The final touches make perfect the peptide-MHC class I repertoire

GE Hammer, T Kanaseki, N Shastri - Immunity, 2007 - cell.com
GE Hammer, T Kanaseki, N Shastri
Immunity, 2007cell.com
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved
peptides on the cell surface for immune surveillance by CD8+ T cells. The pathway for
generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I)
repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides
for MHC I are customized by the ER aminopeptidase associated with antigen processing
and by dynamic interactions within the MHC peptide-loading complex. Failure to customize …
Summary
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8+ T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.
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