MicroRNA-709 mediates acute tubular injury through effects on mitochondrial function
Y Guo, J Ni, S Chen, M Bai, J Lin, G Ding… - Journal of the …, 2018 - journals.lww.com
Mitochondrial dysfunction has important roles in the pathogenesis of AKI, yet therapeutic
approaches to improve mitochondrial function remain limited. In this study, we investigated
the pathogenic role of microRNA-709 (miR-709) in mediating mitochondrial impairment and
tubular cell death in AKI. In a cisplatin-induced AKI mouse model and in biopsy samples of
human AKI kidney tissue, miR-709 was significantly upregulated in the proximal tubular cells
(PTCs). The expression of miR-709 in the renal PTCs of patients with AKI correlated with the …
approaches to improve mitochondrial function remain limited. In this study, we investigated
the pathogenic role of microRNA-709 (miR-709) in mediating mitochondrial impairment and
tubular cell death in AKI. In a cisplatin-induced AKI mouse model and in biopsy samples of
human AKI kidney tissue, miR-709 was significantly upregulated in the proximal tubular cells
(PTCs). The expression of miR-709 in the renal PTCs of patients with AKI correlated with the …