Cellular and molecular mechanisms of AKI

A Agarwal, Z Dong, R Harris, P Murray… - Journal of the …, 2016 - journals.lww.com
In this article, we review the current evidence for the cellular and molecular mechanisms of
AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using ischemic
AKI as a model. Highlighted are the clinical relevance of cellular and molecular targets that
have been investigated in experimental models of ischemic AKI and how such models might
be improved to optimize translation into successful clinical trials. In particular, development
of more context-specific animal models with greater relevance to human AKI is urgently …