The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO 3− salvage transporter human Na+-HCO 3− cotransport …
Cystic fibrosis transmembrane conductance regulator (CFTR) regulates both HCO 3−
secretion and HCO 3− salvage in secretory epithelia. At least two luminal transporters
mediate HCO 3− salvage, the Na+/H+ exchanger (NHE3) and the Na+-HCO 3− cotransport
(NBC3). In a previous work, we show that CFTR interacts with NHE3 to regulate its activity
(Ahn, W., Kim, KW, Lee, JA, Kim, JY, Choi, JY, Moe, OM, Milgram, SL, Muallem, S., and Lee,
MG (2001) J. Biol. Chem. 276, 17236–17243). In this work, we report that transient or stable …
secretion and HCO 3− salvage in secretory epithelia. At least two luminal transporters
mediate HCO 3− salvage, the Na+/H+ exchanger (NHE3) and the Na+-HCO 3− cotransport
(NBC3). In a previous work, we show that CFTR interacts with NHE3 to regulate its activity
(Ahn, W., Kim, KW, Lee, JA, Kim, JY, Choi, JY, Moe, OM, Milgram, SL, Muallem, S., and Lee,
MG (2001) J. Biol. Chem. 276, 17236–17243). In this work, we report that transient or stable …
