Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte …
HS Kim, R Asmis - Free Radical Biology and Medicine, 2017 - Elsevier
HS Kim, R Asmis
Free Radical Biology and Medicine, 2017•ElsevierMAPK pathways play a critical role in the activation of monocytes and macrophages by
pathogens, signaling molecules and environmental cues and in the regulation of
macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the
main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1
in monocytes and macrophages in response to metabolic stress leads to dysregulation of
monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte …
pathogens, signaling molecules and environmental cues and in the regulation of
macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the
main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1
in monocytes and macrophages in response to metabolic stress leads to dysregulation of
monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte …
Abstract
MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.
Elsevier