Alterations of intravascular volume: influence on renal susceptibility to ischemic injury
RA Zager - The Journal of laboratory and clinical medicine, 1986 - translationalres.com
The purpose of this investigation was to test whether alterations of intravascular volume
change renal susceptibility to ischemic injury. Acute volume depletion (2% body weight; by
furosemide injection or by hemorrhage) or volume expansion (10% body weight; by saline
infusion) was induced in Sprague-Dawley rats. The effects of these interventions on renal
blood flow (RBF), mean arterial blood pressure (MAP), glomerular filtration rate (GFR), and
renal adenine nucleotide content were assessed by comparison with values observed in …
change renal susceptibility to ischemic injury. Acute volume depletion (2% body weight; by
furosemide injection or by hemorrhage) or volume expansion (10% body weight; by saline
infusion) was induced in Sprague-Dawley rats. The effects of these interventions on renal
blood flow (RBF), mean arterial blood pressure (MAP), glomerular filtration rate (GFR), and
renal adenine nucleotide content were assessed by comparison with values observed in …