Acute tubular necrosis (ATN) is a syndrome of intrinsic renal failure secondary to ischemic or
toxic insults. The histopathologic findings of ATN are inconstant. When present, they are
limited to the tubulo-interstitium and often subtle despite profound dysfunction. Experimental
models of ATN in healthy animals commonly use single insults that result in extensive injury,
circumstances that do not parallel the human situation. Recently, there has been a shift to
more clinically relevant models using an acute insult superimposed on predisposing factors …