Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives

CD Scripture, WD Figg… - Current …, 2006 - ingentaconnect.com
CD Scripture, WD Figg, A Sparreboom
Current neuropharmacology, 2006ingentaconnect.com
Paclitaxel is an antineoplastic agent derived from the bark of the western yew, Taxus
brevifolia, with a broad spectrum of activity. Because paclitaxel promotes microtubule
assembly, neurotoxicity is one of its side effects. Clinical use of paclitaxel has led to
peripheral neuropathy and this has been demonstrated to be dependent upon the dose
administered, the duration of the infusion, and the schedule of administration. Vehicles in the
drug formulation, for example Cremophor in TaxolŽ, have been investigated for their …
Paclitaxel is an antineoplastic agent derived from the bark of the western yew, Taxus brevifolia, with a broad spectrum of activity. Because paclitaxel promotes microtubule assembly, neurotoxicity is one of its side effects. Clinical use of paclitaxel has led to peripheral neuropathy and this has been demonstrated to be dependent upon the dose administered, the duration of the infusion, and the schedule of administration. Vehicles in the drug formulation, for example Cremophor in TaxolŽ, have been investigated for their potential to induce peripheral neuropathy. A variety of neuroprotective agents have been tested in animal and clinical studies to prevent paclitaxel neurotoxicity. Recently, novel paclitaxel formulations have been developed to minimize toxicities. This review focuses on recent advances in the etiology of paclitaxel-mediated peripheral neurotoxicity, and discusses current and ongoing strategies for amelioration of this side effect.
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