Changes in pancreatic islets in aging Wistar and Zucker rats: a histochemical and ultrastructural morphometric study

V Ogneva, B Nikolov - Mechanisms of ageing and development, 1994 - Elsevier
Morphometrical and cytochemical techniques have been applied to characterize the islets of
Langerhans tissue in lean and obese Zucker fa/fa and Wistar rats. The changes in cytologic
composition correlated with levels of serum glucose and lipids in obese rats and progressed
significantly with increasing body weight. Histochemical and enzyme abnormalities
observed in Zucker fa/fa and Wistar rats reflect the degenerative and reactive processes in
the pancreas: a decrease in Krebs cycle and pentose pathway and increased lysosomal …