[HTML][HTML] A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts

JW Neal, NA Clipstone - Journal of Biological Chemistry, 2003 - ASBMB
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway is best known
for its role in T lymphocyte activation. However, it has become increasingly apparent that this
signaling pathway is also involved in the regulation of cell growth and development in a
wide variety of different tissues and cell types. Here we have investigated the effects of
sustained NFATc1 signaling on the growth and differentiation of the murine 3T3-L1
preadipocyte cell line. Remarkably, we find that expression of a constitutively active NFATc1 …