Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation
BO King, ESH Whittow, DL Serna, BU Jones… - ASAIO …, 2001 - journals.lww.com
Abstract Ventricular Assist Devices (VADs) have been used as bridges to heart
transplantation. However, VAD circulation is complicated by the incidence of
thromboembolism, prolonged bleeding, and activation of the inflammatory cascade. We
hypothesize that platelet and neutrophil activation are inter-related and linked to the
activation of the glycoprotein (GP) IIb/IIIa platelet receptor. The purpose of this study is to
evaluate the effects of Tirofiban, a platelet GP IIb/IIIa receptor inhibitor, on platelet and …
transplantation. However, VAD circulation is complicated by the incidence of
thromboembolism, prolonged bleeding, and activation of the inflammatory cascade. We
hypothesize that platelet and neutrophil activation are inter-related and linked to the
activation of the glycoprotein (GP) IIb/IIIa platelet receptor. The purpose of this study is to
evaluate the effects of Tirofiban, a platelet GP IIb/IIIa receptor inhibitor, on platelet and …