Pathophysiology of transfusion-related acute lung injury
MR Looney, BM Gilliss, MA Matthay - Current opinion in …, 2010 - journals.lww.com
MR Looney, BM Gilliss, MA Matthay
Current opinion in hematology, 2010•journals.lww.comTRALI requires an immune priming step followed by transfusion of a blood product with
either leukocyte allo-antibodies or biological response modifiers. TRALI invokes an acute
immune response dominated by neutrophils interacting with platelets and the lung
endothelium.
either leukocyte allo-antibodies or biological response modifiers. TRALI invokes an acute
immune response dominated by neutrophils interacting with platelets and the lung
endothelium.
Summary
TRALI requires an immune priming step followed by transfusion of a blood product with either leukocyte allo-antibodies or biological response modifiers. TRALI invokes an acute immune response dominated by neutrophils interacting with platelets and the lung endothelium.
Lippincott Williams & Wilkins