Placental volume, as measured by 3-dimensional sonography and levels of maternal plasma cell-free fetal DNA
T Wataganara, M Metzenbauer, I Peter… - American journal of …, 2005 - Elsevier
OBJECTIVE: Measurement of cell-free fetal (cff) DNA in maternal plasma may have clinical
application in prenatal screening for fetal Down syndrome and preeclampsia. Little is known
regarding the tissue of origin of these fetal-derived sequences. We tested the hypothesis that
if the placenta is the major contributor of cff DNA, then an increased placental volume should
be associated with higher maternal plasma cff DNA levels. STUDY DESIGN: We enrolled
143 pregnant women who underwent first-trimester placental volume measurement using 3 …
application in prenatal screening for fetal Down syndrome and preeclampsia. Little is known
regarding the tissue of origin of these fetal-derived sequences. We tested the hypothesis that
if the placenta is the major contributor of cff DNA, then an increased placental volume should
be associated with higher maternal plasma cff DNA levels. STUDY DESIGN: We enrolled
143 pregnant women who underwent first-trimester placental volume measurement using 3 …
