Down syndrome and cell-free fetal DNA in archived maternal serum
T Lee, ES LeShane, GM Messerlian, JA Canick… - American journal of …, 2002 - Elsevier
Objective: Increased levels of cell-free fetal DNA (f-DNA) in the maternal circulation are a
potential noninvasive marker for fetal Down syndrome. Our objectives were to (1) determine
whether f-DNA could be quantified by using archived serum and amniotic fluid,(2) examine
whether serum f-DNA levels are elevated in Down syndrome pregnancies in a case-control
series matched for gestational age and duration of sample storage, and (3) determine
whether f-DNA levels are elevated in the amniotic fluid of Down syndrome fetuses. Study …
potential noninvasive marker for fetal Down syndrome. Our objectives were to (1) determine
whether f-DNA could be quantified by using archived serum and amniotic fluid,(2) examine
whether serum f-DNA levels are elevated in Down syndrome pregnancies in a case-control
series matched for gestational age and duration of sample storage, and (3) determine
whether f-DNA levels are elevated in the amniotic fluid of Down syndrome fetuses. Study …