A molecular signature of an arrest of descent in human parturition
OBJECTIVE: This study was undertaken to identify the molecular basis of an arrest of
descent. STUDY DESIGN: Human myometrium was obtained from women in term labor (TL;
n= 29) and arrest of descent (AODes; n= 21). Gene expression was characterized using
Illumina HumanHT-12 microarrays. A moderated Student t test and false discovery rate
adjustment were applied for analysis. Confirmatory quantitative reverse transcription–
polymerase chain reaction and immunoblot were performed in an independent sample set …
descent. STUDY DESIGN: Human myometrium was obtained from women in term labor (TL;
n= 29) and arrest of descent (AODes; n= 21). Gene expression was characterized using
Illumina HumanHT-12 microarrays. A moderated Student t test and false discovery rate
adjustment were applied for analysis. Confirmatory quantitative reverse transcription–
polymerase chain reaction and immunoblot were performed in an independent sample set …