Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis

GP Sacks, K Studena, IL Sargent… - American journal of …, 1998 - Elsevier
OBJECTIVE: Our aim was to seek evidence for circulating leukocyte activation in
preeclampsia. STUDY DESIGN: Whole blood flow cytometric techniques were used to
analyze surface markers of activation (CD11b, CD14, CD23, CD49d, CD62L, CD64, CD66b,
HLA-DR) and intracellular reactive oxygen species. Samples were taken from 21 women
with preeclampsia, 21 matched normal pregnant women, 21 healthy nonpregnant controls,
and 6 nonpregnant patients with septicemia. Ten preeclamptic cases were followed up 6 …