[HTML][HTML] The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity
EF Rocnik, P Liu, K Sato, K Walsh, C Vaziri - Journal of Biological …, 2006 - ASBMB
SMOC-2 is a novel member of the SPARC family of matricellular proteins. The purpose of
this study was to determine whether SMOC-2 can modulate angiogenic growth factor activity
and angiogenesis. SMOC-2 was localized in the extracellular periphery of cultured human
umbilical vein endothelial cells (HUVECs). Ectopically expressed SMOC-2 was also
secreted into the tissue culture medium. In microarray profiling experiments, a recombinant
SMOC-2 adenovirus induced the expression of transcripts required for cell cycle progression …
this study was to determine whether SMOC-2 can modulate angiogenic growth factor activity
and angiogenesis. SMOC-2 was localized in the extracellular periphery of cultured human
umbilical vein endothelial cells (HUVECs). Ectopically expressed SMOC-2 was also
secreted into the tissue culture medium. In microarray profiling experiments, a recombinant
SMOC-2 adenovirus induced the expression of transcripts required for cell cycle progression …