[CITATION][C] The effect of high oxygen concentrations and hypothermia on the lung of the newborn mouse

B Hellstroem, A Nergårdh - Acta Pædiatrica, 1965 - Wiley Online Library
B Hellstroem, A Nergårdh
Acta Pædiatrica, 1965Wiley Online Library
There are numerous reports in the literature of experimental studies on pulmonary damage
induced by oxygen poisoning. They have had a special pediatric interest, since in some of
them a histological picture similar to hyaline membrane disease of newborn infants has
been produced. However, adult animals have been used in most of these investigations [4],
and only a few studies have been made on immature lungs [5, 81. This is surprising
because newborn animals usually have a much greater tolerance to high concentrations of …
There are numerous reports in the literature of experimental studies on pulmonary damage induced by oxygen poisoning. They have had a special pediatric interest, since in some of them a histological picture similar to hyaline membrane disease of newborn infants has been produced. However, adult animals have been used in most of these investigations [4], and only a few studies have been made on immature lungs [5, 81. This is surprising because newborn animals usually have a much greater tolerance to high concentrations of oxygen when compared to adults, and a different effect from pulmonary exposure might be expected. It has recently been claimed [9] that lung Iesions in newborn animals, except for the guineapig, can be produced only by combining the exposure to oxygen with vagotomy, intratracheal injection of foreign material, or other significant insult. The need for prolonged administration of high concentrations of oxygen in the respiratory distress syndrome of the newborn infant makes it necessary to know more about the possible deleterious effect on immature lung tissue.
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