Proteomic architecture of valvular extracellular matrix: FNDC1 and MXRA5 are new biomarkers of aortic stenosis
R Bouchareb, S Guauque-Olarte, J Snider… - Basic to Translational …, 2021 - jacc.org
R Bouchareb, S Guauque-Olarte, J Snider, D Zaminski, A Anyanwu, P Stelzer, D Lebeche
Basic to Translational Science, 2021•jacc.orgThis study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve
calcification with mass spectrometry, and further validated in an independent human cohort
using RNAseq data. The study reveals that valve calcification is associated with significant
disruption in ECM and metabolic pathways, and highlights a strong connection between
metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel
ECM biomarkers in calcified valves, electing them as potential targets in the development …
calcification with mass spectrometry, and further validated in an independent human cohort
using RNAseq data. The study reveals that valve calcification is associated with significant
disruption in ECM and metabolic pathways, and highlights a strong connection between
metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel
ECM biomarkers in calcified valves, electing them as potential targets in the development …
Summary
This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.
jacc.org