High prevalence of amyloid in 150 surgically removed heart valves—a comparison of histological and clinical data reveals a correlation to atheroinflammatory …
AV Kristen, PA Schnabel, B Winter, BM Helmke… - Cardiovascular …, 2010 - Elsevier
INTRODUCTION: The prevalence, pathophysiology, and clinical indicators of valvular
amyloid deposition have not been clarified yet. METHODS: One hundred fifty surgically
resected heart valve specimens [67.4±1.0 years; aortic stenosis (AS), n= 100; aortic
regurgitation, n= 19; mitral stenosis, n= 7; mitral regurgitation, n= 24] were qualitatively,
semiquantitatively, and immunohistochemically analyzed and correlated with clinical data.
RESULTS: Amyloid was found in 83/150 specimens with highest prevalence in AS (74/100) …
amyloid deposition have not been clarified yet. METHODS: One hundred fifty surgically
resected heart valve specimens [67.4±1.0 years; aortic stenosis (AS), n= 100; aortic
regurgitation, n= 19; mitral stenosis, n= 7; mitral regurgitation, n= 24] were qualitatively,
semiquantitatively, and immunohistochemically analyzed and correlated with clinical data.
RESULTS: Amyloid was found in 83/150 specimens with highest prevalence in AS (74/100) …
