(Pro) renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis
T Peltonen, J Näpänkangas, P Ohtonen, J Aro… - Atherosclerosis, 2011 - Elsevier
BACKGROUND: There is increasing evidence that renin–angiotensin system (RAS) may
play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS),
but the gene expression or function of (pro) renin receptor ((P) RR), prorenin and renin or
angiotensin converting enzyme 2 (ACE2)/angiotensin-(1-7)/Mas receptor axis in calcific
aortic valve disease is not known. METHODS AND RESULTS: We characterized expression
of (P) RR, ACE2 and Mas receptor as well as renin, prorenin and angiotensin II type 2 (AT2) …
play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS),
but the gene expression or function of (pro) renin receptor ((P) RR), prorenin and renin or
angiotensin converting enzyme 2 (ACE2)/angiotensin-(1-7)/Mas receptor axis in calcific
aortic valve disease is not known. METHODS AND RESULTS: We characterized expression
of (P) RR, ACE2 and Mas receptor as well as renin, prorenin and angiotensin II type 2 (AT2) …
