An update on the pathophysiology of atopic dermatitis
K Malik, KD Heitmiller, T Czarnowicki - Dermatologic Clinics, 2017 - derm.theclinics.com
Atopic dermatitis (AD) is recognized as a multifactorial, heterogeneous disease
characterized by different clinical phenotypes based on interactions of susceptibility genes,
environmental factors, impaired skin barrier integrity, and immune dysregulation. Although
barrier impairment and immune dysregulation play major roles in pathogenesis, their
sequential order is unclear. The outside-in theory suggests that dysfunctional epidermal
barrier incites the disease with secondary immunologic changes. Conversely, the inside-out …
characterized by different clinical phenotypes based on interactions of susceptibility genes,
environmental factors, impaired skin barrier integrity, and immune dysregulation. Although
barrier impairment and immune dysregulation play major roles in pathogenesis, their
sequential order is unclear. The outside-in theory suggests that dysfunctional epidermal
barrier incites the disease with secondary immunologic changes. Conversely, the inside-out …
