Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy
Current opinion in immunology, 2014•Elsevier
Highlights•ILC2 cells are potent effectors of type 2 inflammation.•ILC2 cells are present in
the skin and elevated and activated in atopic dermatitis.•ILC2 cells respond to epithelial
barrier disruption.•ILC2 cells can contribute to allergic sensitization.Type 2 immune
responses in the skin cause a variety of pathologies, including urticaria and atopic
dermatitis. Traditionally, CD4+ helper T cells have been implicated in the pathogenesis of
these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell …
the skin and elevated and activated in atopic dermatitis.•ILC2 cells respond to epithelial
barrier disruption.•ILC2 cells can contribute to allergic sensitization.Type 2 immune
responses in the skin cause a variety of pathologies, including urticaria and atopic
dermatitis. Traditionally, CD4+ helper T cells have been implicated in the pathogenesis of
these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell …
Highlights
- ILC2 cells are potent effectors of type 2 inflammation.
- ILC2 cells are present in the skin and elevated and activated in atopic dermatitis.
- ILC2 cells respond to epithelial barrier disruption.
- ILC2 cells can contribute to allergic sensitization.
Type 2 immune responses in the skin cause a variety of pathologies, including urticaria and atopic dermatitis. Traditionally, CD4+ helper T cells have been implicated in the pathogenesis of these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell, has emerged as an important contributor to skin allergies. In this review, we summarize our current knowledge of the role ILC2 cells play in the physiology and pathology of mouse and human skin.
Elsevier