Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum
PS Gao, NM Rafaels, T Hand, T Murray… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Loss-of-function null mutations R501X and 2282del4 in the skin barrier
gene, filaggrin (FLG), represent the most replicated genetic risk factors for atopic dermatitis
(AD). Associations have not been reported in African ancestry populations. Atopic dermatitis
eczema herpeticum (ADEH) is a rare but serious complication of AD resulting from
disseminated cutaneous herpes simplex virus infections. OBJECTIVE: We aimed to
determine whether FLG polymorphisms contribute to ADEH susceptibility. METHODS: Two …
gene, filaggrin (FLG), represent the most replicated genetic risk factors for atopic dermatitis
(AD). Associations have not been reported in African ancestry populations. Atopic dermatitis
eczema herpeticum (ADEH) is a rare but serious complication of AD resulting from
disseminated cutaneous herpes simplex virus infections. OBJECTIVE: We aimed to
determine whether FLG polymorphisms contribute to ADEH susceptibility. METHODS: Two …