Neuronal damage and cognitive impairment associated with hypoglycemia: an integrated view

G Languren, T Montiel, A Julio-Amilpas… - Neurochemistry …, 2013 - Elsevier
The aim of the present review is to offer a current perspective about the consequences of
hypoglycemia and its impact on the diabetic disorder due to the increasing incidence of
diabetes around the world. The main consequence of insulin treatment in type 1 diabetic
patients is the occurrence of repetitive periods of hypoglycemia and even episodes of
severe hypoglycemia leading to coma. In the latter, selective neuronal death is observed in
brain vulnerable regions both in humans and animal models, such as the cortex and the …