Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
IA Simpson, KR Chundu, T Davies‐Hill… - Annals of Neurology …, 1994 - Wiley Online Library
IA Simpson, KR Chundu, T Davies‐Hill, WG Honer, P Davies
Annals of Neurology: Official Journal of the American Neurological …, 1994•Wiley Online LibraryGlucose metabolism is depressed in the temporal and parietal regions of the cortex in
patients with Alzheimer's disease. We measured the concentrations of two glucose
transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and
patients with Alzheimer's disease. The concentrations of both transporters were reduced in
the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the
putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss …
patients with Alzheimer's disease. We measured the concentrations of two glucose
transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and
patients with Alzheimer's disease. The concentrations of both transporters were reduced in
the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the
putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss …
Abstract
Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. The concentrations of both transporters were reduced in the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss of synapses, and should be considered as a potential cause of the deficits in glucose metabolism.
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