Autosomal recessive causes likely in early-onset Alzheimer disease
Objectives To determine the genetic contribution to non–autosomal dominant early-onset
Alzheimer disease (EOAD)(onset age≤ 60 years) cases and identify the likely mechanism
of inheritance in those cases. Design A liability threshold model of disease was used to
estimate heritability of EOAD and late-onset Alzheimer disease (AD) using concordance for
AD among parent-offspring pairs. Setting The Uniform Data Set, whose participants were
collected from 32 US Alzheimer's Disease Centers, maintained by the National Alzheimer's …
Alzheimer disease (EOAD)(onset age≤ 60 years) cases and identify the likely mechanism
of inheritance in those cases. Design A liability threshold model of disease was used to
estimate heritability of EOAD and late-onset Alzheimer disease (AD) using concordance for
AD among parent-offspring pairs. Setting The Uniform Data Set, whose participants were
collected from 32 US Alzheimer's Disease Centers, maintained by the National Alzheimer's …
