Inhibition of MARCO ameliorates silica-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition
M Yang, X Qian, N Wang, Y Ding, H Li, Y Zhao, S Yao - Toxicology Letters, 2019 - Elsevier
Epithelial-mesenchymal transition (EMT) is linked to fibrosis following exposure to silica. The
scavenger receptor, macrophage receptor with collagenous structure (MARCO) plays an
important role in silica-induced inflammation, however, the effect of MARCO on silica-
induced fibrosis has not been identified. We hypothesized that MARCO would regulate EMT
and be involved in the development of silicosis. Herein, we found that MARCO was highly
expressed in lung tissue after exposure to silica and a MARCO inhibitor PolyG could …
scavenger receptor, macrophage receptor with collagenous structure (MARCO) plays an
important role in silica-induced inflammation, however, the effect of MARCO on silica-
induced fibrosis has not been identified. We hypothesized that MARCO would regulate EMT
and be involved in the development of silicosis. Herein, we found that MARCO was highly
expressed in lung tissue after exposure to silica and a MARCO inhibitor PolyG could …