[HTML][HTML] Toll-like receptor 9 stimulation induces aberrant expression of a proliferation-inducing ligand by tonsillar germinal center B cells in IgA nephropathy
M Muto, B Manfroi, H Suzuki, K Joh… - Journal of the …, 2017 - journals.lww.com
The TNF family member a proliferation-inducing ligand (APRIL; also known as TNFSF13),
produced by myeloid cells, participates in the generation and survival of antibody–producing
plasma cells. We studied the potential role of APRIL in the pathogenesis of IgA nephropathy
(IgAN). We found that a significant proportion of germinal centers (GCs) in tonsils of patients
with IgAN contained cells aberrantly producing APRIL, contributing to an overall
upregulation of tonsillar APRIL expression compared with that in tonsils of control patients …
produced by myeloid cells, participates in the generation and survival of antibody–producing
plasma cells. We studied the potential role of APRIL in the pathogenesis of IgA nephropathy
(IgAN). We found that a significant proportion of germinal centers (GCs) in tonsils of patients
with IgAN contained cells aberrantly producing APRIL, contributing to an overall
upregulation of tonsillar APRIL expression compared with that in tonsils of control patients …