Abrogation of bleomycin-induced lung fibrosis by nitric oxide synthase inhibitor, aminoguanidine in mice
SN Giri, I Biring, T Nguyen, Q Wang, DM Hyde - Nitric Oxide, 2002 - Elsevier
The effects of aminoguanidine (AG), a specific inhibitor of inducible nitric oxide synthase, on
the bleomycin (BL)-induced lung fibrosis was evaluated in mice. The animals were placed
into five groups: saline (SA)-instilled drinking water (SA+ H2O), saline-instilled drinking
water containing 0.5% AG (SA+ 0.5% AG), BL-instilled drinking water (BL+ H2O), BL-
instilled drinking water containing 0.2% AG (BL+ 0.2% AG), and BL-instilled drinking water
containing 0.5% AG (BL+ 0.5% AG). The mice had free access to H2O or H2O containing AG …
the bleomycin (BL)-induced lung fibrosis was evaluated in mice. The animals were placed
into five groups: saline (SA)-instilled drinking water (SA+ H2O), saline-instilled drinking
water containing 0.5% AG (SA+ 0.5% AG), BL-instilled drinking water (BL+ H2O), BL-
instilled drinking water containing 0.2% AG (BL+ 0.2% AG), and BL-instilled drinking water
containing 0.5% AG (BL+ 0.5% AG). The mice had free access to H2O or H2O containing AG …
