Cardioprotection with cariporide, a sodium-proton exchanger inhibitor, after prolonged ischemia and reperfusion in senescent rats
S Besse, S Tanguy, F Boucher, C Le Page… - Experimental …, 2004 - Elsevier
This study investigated the effects of cariporide, an inhibitor of sodium-proton exchanger
(NHE), during myocardial ischemia and reperfusion in senescence. Isolated Langendorff
perfused hearts from 4 (adult) and 24 (senescent) month old male Wistar rats were
submitted to prolonged low-flow ischemia (LFI) at 15% of initial coronary flow (180 min) or to
45 min of LFI (15% of initial coronary flow) followed by 30 min of reperfusion, without or with
cariporide (10− 6M). In senescent hearts, but not in adults, treatment with cariporide during …
(NHE), during myocardial ischemia and reperfusion in senescence. Isolated Langendorff
perfused hearts from 4 (adult) and 24 (senescent) month old male Wistar rats were
submitted to prolonged low-flow ischemia (LFI) at 15% of initial coronary flow (180 min) or to
45 min of LFI (15% of initial coronary flow) followed by 30 min of reperfusion, without or with
cariporide (10− 6M). In senescent hearts, but not in adults, treatment with cariporide during …